Inflammation Immunity & Tumour Biology Lab
PUBLICATIONS
2024
The role of NLRP3 and NLRP12 inflammasomes in glioblastoma
Sushmita Rajkhowa, Sushmita Jha
https://doi.org/10.1038/s41435-024-00309-z
Genes & Immunity
Springer Nature
Innate Immune Receptor NLRX1: Potential Modulator of Glioblastoma Pathophysiology
Durgesh Meena, Divya Shivakumar , Sushmita Rajkhowa , Neermita Bhattacharya , Priya Solanki , Shalini Chhipa , Vikas Janu , Mayank Garg , Jaskaran Singh Gosal, Sushmita Jha
https://doi.org/10.1101/2024.09.19.613932
bioRxiv
Autophagy in glioblastoma: A mechanistic perspective
Durgesh Meena, Sushmita Jha
DOI: 10.1002/ijc.34991
International Journal of Cancer
[Wiley Publication]
2023
The NLR gene family: from discovery to present day
Wei-Chun Chou*, Sushmita Jha*, Michael W. Linhoff, Jenny P.-Y. Ting
Springer Nature
Rapid Detection of Inflammatory Biomarkers using Surface Enhanced Raman Spectroscopy
B. Akilandeshwari, S. Singh, A. Agarwal and S. Jha
IEEE Applied Sensing Conference (APSCON), Bengaluru, India, 2023
doi:10.1109/APSCON56343.2023.10101191
Inflammasome biology Fundamentals, Role in Disease States, and Therapeutic Opportunities. Edited by Pablo Pelegrin, ISBN: 978-0-323-91802-2. Chapter 12: Inflammasome effector functions: a Tale of Fire and Ice.
Sushmita Jha and Jenny P.-Y. Ting
Springer Nature
2021
Protocol for induction and characterization of microglia extracellular traps in murine and human microglia cells
Ishan Agrawal, Nidhi Sharma, Shivanjali Saxena, S. Arvind, Debayani Chakraborty, Debarati Bhunia Chakraborty, Deepak Jha, Surajit Ghatak, Sridhar Epari, Tejpal Gupta, Sushmita Jha
[STAR Protocols]
Dopamine induces functional extracellular traps in microglia
Ishan Agrawal,Nidhi Sharma, Shivanjali Saxena, S. Arvind, Debayani Chakraborty, Debarati Bhunia Chakraborty, Deepak Jha, Surajit Ghatak, Sridhar Epari, Tejpal Gupta, Sushmita Jha
[iScience]
2020
Portable, low‐cost hypoxia chamber for simulating hypoxic environments: Development, characterization and applications
Shivanjali Saxena, Ishan Agrawal, Pratibha Singh, Sushmita Jha
[Medical Devices & Sensors, Wiley Publishing Group]
Comprehensive review of ASC structure and function in immune homeostasis and disease
Ishan Agrawal, Sushmita Jha
[Molecular Biology Reports, Springer]
Obtaining Human Microglia from Adult Human Brain Tissue
Ishan Agrawal, Shivanjali Saxena, Preethika Nair, Deepak Jha, Sushmita Jha
[JOVE]
Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia
Ishan Agrawal, Sushmita Jha
[Frontiers in Aging Neuroscience]
2019
Differential Expression Profile of NLRs and AIM2 in Glioma and Implications for NLRP12 in Glioblastoma
Nidhi Sharma, Shivanjali Saxena, Ishan Agrawal, Shalini Singh, Varsha Srinivasan, S. Arvind, Sridhar Epari, Sushmita Paul, Sushmita Jha
[Scientific Reports, Nature Publishing Group]
Hypoxia chamber for simulating hypoxic environment to study hypoxia related diseases specially cancer.
S Saxena, S Jha
(Patent application number : 201811017208)
Patent
2018
Invited Book Chapter for American society for Microbiology, titled “Myeloid cells in health and disease: a synthesis”, Editor: Siamon Gordon, University of Oxford, Commissioning editor: Greg Payne, American Society for Microbiology, Publisher ASM Press
S Jha, WJ Brickey and JPY Ting
[ISBN 1555819184, 9781555819187]
Book Chapter
NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications
S Singh, S Jha Corresponding Author
[PubMed]
[Molecular Neurobiology]
Evaluation of wound dressing properties of chitin membranes containing nanosilver
R Singh, K Shitiz, S Singh, S Jha, A Singh
[Biomedical Physics & Engineering Express]
2017
A role for the NLR family members NLRC4 and NLRP3 in sterile inflammasome activation in glial cells
H Guo, L Freeman, CN David, WJ Brickey, S Jha, JP Ting
[The Journal of Immunology]
NLRC3 mediated PI3K-mTOR inhibition takes a toll on colon cancer
N Sharma, S Jha Corresponding Author
[Translational Cancer Research]
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
L Freeman, H Guo, CN David, WJ Brickey, S Jha, JPY Ting [PubMed]
[Journal of Experimental Medicine]
Trigonella seed extract ameliorates inflammation via regulation of the inflammasome adaptor protein, ASC
S Jha Corresponding Author, N Sharma, S Suresh, A Debnath
[PubMed][Frontiers in Bioscience]
Role of NOD-like Receptors in Glioma Angiogenesis: Insights into future therapeutic interventions
S Saxena, S Jha Corresponding Author
[PubMed]
[Cytokine & growth factor reviews]
Inflammasomes in Myeloid Cells: Warriors within
S Jha, WJ Brickey, JPY Ting
[PubMed]
[Microbiology spectrum]
2015
NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions
N Sharma, S Jha Corresponding Author
[PubMed]
[Cellular and Molecular Life Sciences]
Holding the inflammatory system in check: NLRs keep it cool
S Jha, JPY Ting
doi: 10.12703/P7-15
[PubMed]
2014
Novel approach for security in wireless sensor network using bio-inspirations
H Rathore, V Badarla, S Jha, A Gupta
[Communication Systems and Networks]
Bio-inspired machine learning based wireless sensor network security
H Rathore, S Jha
[Nature and Biologically Inspired Computing]
MyD88 provides a protective role in long-term radiation-induced lung injury
WJ Brickey, IP Neuringer, W Walton, X Hua, EY Wang, S Jha, GD Sempowski, X Yang, SL Kirby, SL Tilley, JPY Ting
[PubMed]
[International journal of radiation biology]
2012
2010
2009
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18
S Jha, SY Srivastava, WJ Brickey, H Iocca, A Toews, JP Morrison, VS Chen, D Gris, GK Matsushima, JPY Ting
[PubMed]
[Journal of Neuroscience]
Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases
S Jha, JPY Ting
[PubMed]
[The Journal of Immunology]
Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation
KE Roney, BP O'Connor, HWen, EK Holl, EH Guthrie, BK Davis, SW Jones, S Jha, L Sharek, R Garcia-Mata, JE Bear, JPY Ting
[PubMed]
[PLoS One]
J Aitsebaomo, S Srivastava, H Zhang, S Jha, Z Wang, S Winnik, AN Veleva, X Pi, P Lockyer, JE Faber, C Patterson
[PubMed]
[Arteriosclerosis, thrombosis, and vascular biology]
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses
EK Holl, BP O’Connor, TM Holl, KE Roney, AG Zimmermann, S Jha, G Kelsoe, JPY Ting
[PubMed]
[The Journal of Immunology]
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
H Wen, D Gris, Y Lei, S Jha, L Zhang, MTH Huang, WJ Brickey, JPY Ting
[PubMed]
[Nature immunology]